# Tirzepatide vs Semaglutide

This comparison page explains the differences between tirzepatide and semaglutide for GLP-1 weight-loss goals, including mechanism, formats, pricing, side effects, and clinical fit.

Tirzepatide acts on GLP-1 and GIP pathways, while semaglutide acts on GLP-1. Telos RX uses online intake and US-licensed provider review to help match patients to an appropriate option when treatment is clinically suitable.

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> Source: [Telos RX](https://www.telosrx.com/pages/tirzepatide-vs-semaglutide)