Blood-flow medications
Sildenafil, tadalafil and the rest are PDE5 inhibitors. They act on the body’s physical response.
They help the body follow through once desire is already there. They do not create the wanting.
telos rx
PT-141 · Desire
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Desire starts in the brain.
Let’s wake it up.
A peptide that works on desire and arousal, the spark that comes before the moment.
- Works on desire and arousal, not blood flow
- A different approach than blood-flow medications
- Taken at least 45 min before, effects may last several hours
- 100% online, with free, discreet shipping to your door
Pay only if approved.
As low as$249$138per month
Less than $5 a day.* One price, one peptide, no membership fee stacked on top.
*Based on the 12-month plan. Subject to provider approval.
The real problem
Nothing is broken. Something just went quiet.
- The moment arrives, and you feel nothing move.
- You have told yourself it is stress, or work, or the season you are in.
- Your partner has stopped asking, which somehow lands harder than when they asked.
- You looked at the blue pill and thought, that is not the part that stopped working.
- And underneath all of it, the question you do not say out loud: is this just who I am now?
Here is what almost nobody explains. Desire and erection are two different systems. Blood-flow medications act on the second one. They help the body follow through on a signal that has already been sent. If the signal itself never arrives, there is nothing for them to work with. That signal is a brain event, and it runs through a set of receptors most people have never heard of.
What PT-141 actually is
Two different problems. Two different pathways.
Most of this category treats the last step. PT-141 is studied on the first one.
PT-141
Bremelanotide is a melanocortin receptor agonist. It acts centrally, in the brain, not on blood vessels.
It is studied on the desire and arousal signalling that comes before the physical response.
Brain-firstStudied at melanocortin MC3R and MC4R receptors, a different pathway from blood-flow medications.
Men and womenBremelanotide has been studied in both. The FDA approval covers premenopausal women only. Use in men is off-label.
At least 45 minApproved labeling directs dosing at least 45 minutes before anticipated activity, up to one dose in 24 hours.
On demandTaken only when you choose. It is not a daily pill and there is no schedule to keep.
Compounded PT-141 is not FDA-approved. Onset and duration vary from person to person. A licensed provider decides whether PT-141 is appropriate for you, and approval is not guaranteed.
The evidence, stated plainly
What the research actually says. Including the parts that are not flattering.
Bremelanotide is a melanocortin receptor agonist that acts on the central nervous system. This is a different mechanism from PDE5 inhibitors, which work on blood flow.
Molinoff et al, Ann N Y Acad SciThe FDA approved bremelanotide as Vyleesi in 2019 for acquired, generalized hypoactive sexual desire disorder in premenopausal women. That is its only approved indication. Prescribing it to men is off-label.
FDA approval, 2019The Phase 3 evidence comes from the two RECONNECT trials, conducted in premenopausal women with acquired, generalized HSDD.
Kingsberg et al, Obstet Gynecol 2019 (PMID 31599840)In the 52-week open-label extension, the most common adverse events were nausea in 40.4% of participants, flushing in 20.6% and headache in 12.0%. Nausea was usually transient. We would rather you read that here than find it later.
Simon et al, Obstet Gynecol 2019 (PMID 31599847)Published research on bremelanotide is not research on this compounded product, and results in a trial population are not a prediction of your result. Individual results vary and are not guaranteed.
How it works
Four steps. Most of it happens without you.
Tell us what changed
A five-minute intake, online, in your own words. No waiting room and no appointment to book.
A provider reviews it
A US-licensed provider reads your history and decides whether PT-141 is appropriate for you. Approval is not guaranteed.
It arrives, plainly packaged
Shipped free from a licensed US compounding pharmacy. Nothing on the box says what is inside.
Adjust whenever
Message your care team any time. Dose changes and questions cost nothing extra.
The offer
One clear price. As low as $138 per month.
Every plan includes the full telos rx care experience. A licensed provider reviews your intake first. If you are not approved, or PT-141 is not right for you, you pay nothing.
As low as
$249
$138per month
Less than $5 a day, based on the 12-month plan. Cancel anytime.
✓
Provider-set dosing, not a templateA licensed provider sets your protocol from your intake and adjusts it as you go.
✓
Used on demand, on your termsOnly when you choose. No daily pill, no schedule to keep, no build-up period.
✓
Unlimited US care-team messagingReal people, any time, no per-message charge and no phone tree.
✓
Free discreet shippingPlain packaging from a licensed US compounding pharmacy. What is in the box is your business.
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FSA/HSA eligibleUse pre-tax dollars where eligible.
✓
Cancel anytime, one clickFrom your patient portal. No retention call and no cancellation fee.
Our promise
A licensed provider reviews your intake before anything ships. If you are not approved, you pay nothing.
Why people explore it
What draws people to PT-141
It works on the wanting
The reason most people come looking. PT-141 is studied on the brain signalling behind desire and arousal, not on the physical response further down the chain.
A genuinely different mechanism
If blood-flow medications did not help, that is information. PT-141 acts through a different pathway, which is exactly why people who have already tried the usual options look at it.
Present, not performing
People describe feeling more emotionally present with their partner rather than managing a performance. That is a described experience, not a promised outcome.
You stay in control
Taken only when you choose, which is a very different relationship than a pill you take every day whether or not the evening goes anywhere.
Descriptions of patient experience come from published clinical literature, not from telos rx patient data. PT-141 does not work for everyone and individual results vary.
Straight answers before you start
How is PT-141 different from Viagra or Cialis?
They solve different problems. Sildenafil and tadalafil are PDE5 inhibitors that act on blood flow, helping the body follow through once desire is already present. PT-141 is bremelanotide, a melanocortin receptor agonist that acts centrally in the brain, on the desire and arousal signalling that comes before that. If blood-flow medications did not help you, it may be because blood flow was not the limiting step.
How fast does it work, and how long does it last?
Approved labeling for bremelanotide directs dosing at least 45 minutes before anticipated sexual activity, with no more than one dose in any 24 hours and no more than eight doses per month. Subjective effects are commonly reported for several hours after dosing. Onset and duration vary from person to person, and your provider will give you dosing guidance specific to you.
Is PT-141 FDA-approved?
Bremelanotide is FDA-approved as Vyleesi for acquired, generalized hypoactive sexual desire disorder in premenopausal women. That is the only approved indication. The compounded PT-141 prescribed through telos rx is not an FDA-approved product. It is prepared by a licensed US compounding pharmacy against a valid prescription, and it has not been reviewed by the FDA for safety, effectiveness or quality.
Does it work for men?
Bremelanotide has been studied in men as well as women, but the FDA approval covers premenopausal women only. Prescribing it to men is off-label, which means a licensed provider is using their clinical judgment outside the approved indication. That is legal and common in medicine, and you should know that is what is happening. Your provider will discuss whether it is appropriate for you.
How is it taken?
As a small subcutaneous injection, meaning into the tissue just under the skin, which you give yourself at home before anticipated activity. Your care team walks you through exactly how to prepare and administer it, and you can message them any time you have a question.
What are the side effects?
The most common are nausea, flushing and headache. In the 52-week extension study of bremelanotide, nausea was reported by 40.4% of participants, flushing by 20.6% and headache by 12.0%. Nausea was usually transient. Injection-site reactions, a temporary rise in blood pressure and, with repeated dosing, darkening of skin in small patches have also been reported. PT-141 is not appropriate if you have uncontrolled high blood pressure or known cardiovascular disease. Tell your provider about every medication you take.
Will my order be discreet?
Yes. It ships in plain packaging with no telos rx branding and no medication name on the outside of the box. The billing descriptor is not explicit either.
Can I cancel?
Yes, in one click from your patient portal. No retention call and no cancellation fee. Cancelling stops future billing cycles. Once an order has been transmitted to the pharmacy it cannot be cancelled or refunded, so if you need to stop an order already placed, message us through your portal immediately.
Desire, rekindled.
Five minutes online. A US-licensed provider reviews your intake and decides whether PT-141 is appropriate for you, and approval is not guaranteed. Approved, and it ships free in plain packaging. As low as $138 per month.
100% online, no appointments. Provider-reviewed. Free discreet shipping. Cancel anytime. PT-141 is not FDA-approved and requires medical approval. Results vary.
Important safety information
Compounded PT-141 is not FDA-approved and has not been evaluated by the FDA for safety, effectiveness or quality. Bremelanotide is FDA-approved as Vyleesi for acquired, generalized hypoactive sexual desire disorder in premenopausal women only; that is its sole approved indication, and any other use, including use in men, is off-label and determined by a licensed provider. PT-141 is available only by prescription and is subject to medical approval by a licensed provider based on your online intake. Approval is not guaranteed. This is an asynchronous online telehealth service and is not a substitute for in-person or emergency care.
Common side effects may include nausea, flushing, headache, fatigue, injection-site reactions and a temporary increase in blood pressure. Focal darkening of the skin has been reported with repeated dosing. Do not use PT-141 if you have uncontrolled high blood pressure or known cardiovascular disease. Tell your provider about all medications you take, including naltrexone and PDE5 inhibitors. Seek medical attention if you experience a severe or persistent reaction.
PT-141 is not intended to diagnose, treat, cure or prevent any disease. Published research on bremelanotide was conducted on the approved product, not on this compounded preparation, and trial results are not a prediction of your result. Individual results vary and are not guaranteed. Testimonials reflect one individual’s experience and are not typical or a guarantee of results. Availability and formulations may vary by state. Prices shown are current as of publication and subject to change.