Comparing TelosRX and DirectDose is mostly a question of which medicine you are looking for. DirectDose is a telehealth service that sells prescription antiparasitic medication, specifically ivermectin and mebendazole capsules, priced at $99.99 for a one-month supply. It does not offer GLP-1 medications. TelosRX is a LegitScript-certified GLP-1 service for weight management, with plans as low as $99 per month. The two do not compete for the same prescription.
If you need a prescription antiparasitic reviewed by a licensed provider, DirectDose is built for exactly that and TelosRX does not offer it. If you want GLP-1 weight management, TelosRX is the only one of the two that offers it. Medication, labs, shipping and provider support sit inside one monthly price.
Start your intake →Quick comparison: TelosRX vs DirectDose
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed. Individual results vary.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth service built around GLP-1 weight management.
The process is asynchronous. You complete a short intake online and a US-licensed provider reviews it, usually within hours. There is no appointment to schedule and nothing to book.
Medications are compounded by licensed US pharmacies, VialsRX and Jungle Jim's, and prescribed by providers at Arora Health Group. Approved orders ship free within two days. Unlimited messaging, provider-managed dose adjustments and quarterly labs are all included at no extra cost. Your monthly price does not change as your dose is titrated.
You can cancel in one click at any time, with no cancellation fee. Compare all four GLP-1 options side by side, or start your treatment.
What is DirectDose?
DirectDose is a telehealth service in a different category entirely. Its catalog is prescription antiparasitic medication, and its site describes ivermectin prescribed "for approved antiparasitic indications" under physician supervision.
Three products are listed: ivermectin 12mg capsules, mebendazole 100mg capsules, and a capsule combining the two. All are dye-free and, per its own FAQ, are dispensed for physician-directed 21-day cycles with 14-day breaks between them. Every order requires a telehealth consultation before medication ships, and you must be 18 or older.
DirectDose names its partners openly, which is worth crediting. Its pharmacy partner is Rush Pharmacy, described as NABP-accredited and state-licensed, and its provider network is LocumTele. It also states that its manufacturing facility is DEA-registered and state-licensed, and that its platform operates in line with HIPAA privacy and security standards.
On coverage, its homepage and FAQ say services are available in 48 of 50 states, excluding California and South Carolina. Its compliance page publishes a separate state-by-state list and flags six states moving to synchronous visits. The two lists are not identical, so check that page for your own state before ordering.
What DirectDose does not offer is any GLP-1 medication. There is no semaglutide, no tirzepatide and no weight-management program anywhere in its published catalog. If that is what brought you here, DirectDose is not the comparison you need.
Medications: what each service offers
TelosRX works in the GLP-1 class. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP agonist. These ingredients form the basis of FDA-approved brands and are widely studied for weight management. For background, see the NIH NIDDK overview of prescription weight-management medications and the FDA announcement on tirzepatide for weight management.
TelosRX offers injectable semaglutide and injectable tirzepatide, plus needle-free oral tirzepatide for people who would rather not inject. There is also a microdosed tirzepatide protocol for anyone who wants to ease in at a lower dose. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality.
DirectDose works in the antiparasitic class. Ivermectin and mebendazole are both prescription medications with established antiparasitic indications, and DirectDose is explicit that a provider must review your case before anything is dispensed. Its own safety copy notes that mild side effects may include dizziness, nausea or diarrhea, and advises against use during pregnancy or breastfeeding unless a physician directs otherwise.
Key takeaway: These services are not alternatives to each other. DirectDose is the one that prescribes antiparasitics. TelosRX is the one that prescribes GLP-1 medications, with labs, shipping and support folded into a single monthly price.
Pricing and transparency
Both publish full prices on their public sites, with no quiz required to see a number. That is genuinely uncommon in telehealth, and both deserve credit for it.
TelosRX prices by monthly plan, with the visit, medication, shipping, quarterly labs and messaging included:
- Semaglutide, injectable: as low as $99 per month
- Microdosed tirzepatide: as low as $116 per month
- Standard injectable tirzepatide: as low as $139 per month
- Oral, needle-free tirzepatide: from $9 a day
That figure does not move when your dose does. A dose increase is a clinical decision, not a billing event.
DirectDose prices by supply length, and charges the same amount for each of its three products: $99.99 for a one-month supply, $179.99 for two months and $259.99 for three months. Each is shown against a higher compare-at price of $149.99, $299.99 and $449.99. Buying longer lowers the effective monthly cost, down to roughly $87 a month on the three-month option.
The refund terms are worth reading side by side, because both services set a bright line and both put it in a different place. DirectDose advertises a 30-day money-back guarantee on its homepage. Its published refund policy is more specific: prescription medications are final once dispensed and shipped. The stated exceptions are a wrong medication or dose, a damaged order, or an order lost in transit, each reported within seven days. Consultation fees are non-refundable once a consultation has been started or completed. At TelosRX, charges are final once a prescription is transmitted to the pharmacy, and you receive a full refund if a provider declines you.
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How the process works
The order of operations is the clearest difference between them.
At TelosRX, you complete the intake first. It takes about five minutes, a US-licensed provider reviews it without an appointment, and approved medication ships with free two-day delivery. If you are not approved, you pay nothing.
At DirectDose, you choose a product and check out first, then complete the medical intake. Your card is pre-authorized rather than charged at that point. A provider in the LocumTele network reviews your information and conducts a consultation. The charge only lands once your intake has been approved. If it is not approved, the pre-authorization is released and you are not charged. The end result is similar, but the sequence differs, so it is worth knowing which one you are signing up for.
Neither service prescribes automatically. Any medication is subject to medical approval by a licensed provider. Begin your TelosRX intake to see if you qualify.
Support and ongoing care
This is where the two models diverge most, and it follows from what each is treating.
DirectDose is built around a defined course of medication. Its published support is an email address with a stated aim of replying within two business days. The site does not describe coaching, lab work, nutrition support or an ongoing care program. For a time-limited antiparasitic course, that is a reasonable scope.
TelosRX is built around a program you stay on. Unlimited messaging with your care team means you are not waiting for the next scheduled visit to ask a question. Dose adjustments are provider-managed, quarterly labs are already paid for inside the monthly price, and cancelling takes one click with no fee.
Weight management is a long project, and the support around the prescription tends to matter as much as the prescription. See what your TelosRX plan includes.
Safety and medical oversight
Both services require provider review before any prescription is issued, both dispense through licensed US pharmacies, and both name those partners publicly rather than leaving them vague.
TelosRX is LegitScript-certified. DirectDose does not display a LegitScript seal on its site and its certification status is not publicly listed, which is not the same as saying it is uncertified. It does state that it is HIPAA-compliant and that its pharmacy partner is NABP-accredited.
GLP-1 medications are not right for everyone. Providers screen for issues including a personal or family history of medullary thyroid cancer, pancreatitis and pregnancy. Side effects are most often digestive, especially early on, and typically ease with gradual dose titration. Share your full medical history at intake on either service, since approval is subject to medical review and is not guaranteed.
Which service is right for you?
Best if you want GLP-1 weight management with one price covering visit, medication, labs, free two-day shipping and unlimited messaging, held flat at every dose, plus a needle-free oral option and a microdosed protocol.
Best if you are specifically seeking a prescription antiparasitic, want clear per-supply pricing, and prefer a named pharmacy and provider network for a defined, time-limited course of medication.
Read that as a category question rather than a head-to-head. If you want a prescription antiparasitic reviewed by a licensed provider, DirectDose is built for that and TelosRX does not offer it. If you want GLP-1 weight management, TelosRX is the only one of the two that provides it. The rate is predictable, and it does not climb with your dose.
Frequently Asked Questions
Does DirectDose offer GLP-1 medications like semaglutide or tirzepatide?
No. DirectDose's published catalog lists prescription antiparasitic medication only: ivermectin 12mg capsules, mebendazole 100mg capsules, and a combination capsule. There is no semaglutide, tirzepatide or weight-management program on its site.
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth service. Medications are compounded by licensed US pharmacies, VialsRX and Jungle Jim's, and every prescription is subject to medical approval by a licensed provider at Arora Health Group.
How much does DirectDose cost?
DirectDose charges the same for each of its three products: $99.99 for a one-month supply, $179.99 for two months and $259.99 for three months. Those are shown against compare-at prices of $149.99, $299.99 and $449.99, and shipping is free on approved US orders.
How much does TelosRX cost?
TelosRX plans are as low as $99 per month for injectable semaglutide, $116 for microdosed tirzepatide and $139 for standard injectable tirzepatide, with oral tirzepatide from $9 a day. The visit, medication, free two-day shipping, quarterly labs and unlimited messaging are all included.
Do I pay before or after a provider reviews me?
At TelosRX you complete the intake first and receive a full refund if a provider declines you. At DirectDose you check out first, but the card is pre-authorized rather than charged, and the hold is released if your intake is not approved.
Which states does each service cover?
DirectDose says its telehealth services are available in 48 of 50 states, excluding California and South Carolina, and publishes a separate state-by-state list on its compliance page. Check that page for your state. At TelosRX, a provider confirms eligibility in your state during intake.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service. DirectDose details, including its catalog, pricing, state coverage and policies, were checked against its public website in September 2026 and may change.
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