Choosing between TelosRX and Ezra for GLP-1 weight loss comes down to price and what surrounds the medication. TelosRX starts at $49 a month, is LegitScript-certified, and includes quarterly labs. Ezra's signature is its price-lock: the rate you join at never rises as your dose titrates up. Both use compounded GLP-1 medication, publish pricing upfront, and require approval by a licensed provider.
For the lowest entry price, LegitScript-certified care, and quarterly labs, TelosRX is the simpler start. Ezra fits if its dose price-lock guarantee is the feature you care about most.
Start your intake →Quick comparison: TelosRX vs Ezra
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth pharmacy. It focuses on GLP-1 weight management with compounded tirzepatide and semaglutide.
The service is asynchronous. You finish a short intake online, and a US-licensed provider reviews it, usually within a few hours. There is no appointment to book.
Medications are compounded by licensed US pharmacies and shipped to your door. You can message your care team anytime, and pricing is published upfront and stays flat as your clinician titrates your dose, so there are no surprises.
Browse the tirzepatide and semaglutide options, or start your treatment.
What is Ezra?
Ezra, at joinezra.com, is an online GLP-1 weight-loss platform with the tagline Weight Loss Made Simple. It is a different company from the full-body MRI screening service of the same name; this comparison covers the weight-loss telehealth platform.
Ezra's signature feature is its member price-lock: your dose may change, your price never will. The rate you join at is locked in even if your treatment plan later requires higher dosages. You complete an online questionnaire, a US-licensed physician reviews it, and approved medication is cold-shipped to your door with tracking. You are not charged unless a physician approves your treatment, no insurance is required, and Ezra is available in all 50 states.
Ezra offers compounded semaglutide from $113 a month and compounded tirzepatide from $135 a month as weekly injections, plus oral semaglutide drops as a needle-free option. Like TelosRX, it also lists wellness protocols such as NAD+ and sermorelin. Its partner pharmacies operate under 503A state regulation and 503B FDA registration. Ezra does not publicly list a LegitScript certification.
Medications: what each program offers
Both programs center on the same drug class. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP agonist.
These ingredients are studied for weight management and are the basis of FDA-approved brands like Wegovy and Zepbound. The compounded versions offered by both TelosRX and Ezra are not FDA-approved.
TelosRX also offers needle-free oral tirzepatide and a microdosed option. Ezra offers its compounded GLP-1s as weekly injections plus oral semaglutide drops. For background, see the NIH NIDDK overview and the FDA note on tirzepatide for weight management.
Key takeaway: Both publish pricing upfront and keep it flat as your dose changes. TelosRX starts much lower, at $49 a month versus $113, is LegitScript-certified, and includes quarterly labs. Ezra's price-lock is genuinely useful, but flat pricing is something TelosRX already includes.
Pricing and transparency
Good news here: both companies publish pricing upfront, neither requires insurance, and both keep your monthly price flat as your clinician titrates your dose. The real difference is the entry point. TelosRX lists every plan before you sign up:
- From $49 a month for microdosed tirzepatide on the 12-month plan
- $99 your first month for standard tirzepatide on the 12-month plan
- $145, $199, or $399 your first month for the 6-month, 3-month, or single-month plans
Ezra publishes flat rates of $113 a month and up for compounded semaglutide and $135 a month and up for compounded tirzepatide, locked at the rate you join at. TelosRX also accepts FSA and HSA and charges no membership fee. Start your intake to see your TelosRX plan price in minutes.
How the process works
Both services are online and asynchronous, so there is no appointment to schedule. TelosRX intake takes about five minutes. A licensed provider reviews it, often within hours, and approved medication ships with free 48-hour delivery.
Ezra uses an online questionnaire reviewed by a US-licensed physician, and approved medication is cold-shipped with trackable delivery at no extra cost. Neither charges you if you are not approved, and neither prescribes automatically. Any medication is subject to medical approval by a licensed provider.
Coaching and ongoing support
TelosRX leans into clinical monitoring. You get unlimited messaging with your care team, dose adjustments as your body changes, and quarterly labs.
Ezra includes physician messaging through your portal for adjustments and questions. Lab work and structured coaching are not detailed.
One is not strictly better. Ezra keeps things simple and centered on its price guarantee. TelosRX adds lab-based monitoring on top of messaging, at a lower entry price.
Safety and medical oversight
Both programs gate medication behind a licensed provider. No one is prescribed automatically.
GLP-1 medications are not for everyone. Providers screen for issues like a personal or family history of medullary thyroid cancer, pancreatitis, and pregnancy. Side effects can include nausea and digestive changes, especially early on.
TelosRX is LegitScript-certified and includes quarterly labs and care-team messaging, so concerns get flagged. Share your full history during intake, since approval is subject to medical review. You can verify the certification status of any telehealth provider on the LegitScript website.
Which service is right for you?
Best for the lowest entry price, needle-free and microdosed options, quarterly-lab clinical support, flat pricing, and LegitScript-certified care.
Best if the dose price-lock guarantee is your top priority, or you want oral semaglutide drops from a simple, all-50-states platform.
For most people who want a low-cost, transparent start with flat pricing, labs, and LegitScript-certified care, TelosRX is the more straightforward choice. If Ezra's price-lock framing appeals to you, it is worth a look, just note that TelosRX's pricing is also flat as your dose changes, from a lower starting point.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth pharmacy. Medications are compounded by licensed US pharmacies, and every prescription is subject to medical approval by a licensed provider.
Are the GLP-1 medications FDA-approved?
The compounded tirzepatide and semaglutide offered by both TelosRX and Ezra are not FDA-approved. They are prepared under federal compounding regulations by licensed US pharmacies.
How much does TelosRX cost compared to Ezra?
TelosRX publishes its pricing, starting from $49 a month (microdosed tirzepatide, 12-month plan), with standard tirzepatide from $99 your first month. Ezra publishes flat rates from $113 a month for compounded semaglutide and $135 a month for compounded tirzepatide, locked at the rate you join at.
Is TelosRX fully online?
Yes. TelosRX is online-first and asynchronous. You finish a short intake, a licensed provider reviews it, and approved medication ships to you. No appointment is required.
Is this the same Ezra as the MRI company?
No. joinezra.com is a GLP-1 weight-loss telehealth platform, a different company from the full-body MRI screening service of the same name. This comparison covers the weight-loss platform.
Do both keep your price flat as your dose increases?
Yes. Ezra's member price-lock keeps your joining rate as your dose titrates up, and TelosRX's GLP flat pricing works the same way: your monthly cost does not change as your clinician adjusts your dose. The difference is the entry point, from $49 at TelosRX versus from $113 at Ezra.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.
Start your private evaluation at TelosRX.