Comparing TelosRX and Medi-Weightloss for GLP-1 weight loss reveals a clear fork: TelosRX is fully online with prices from $49/mo, while Medi-Weightloss is a physician-supervised in-person clinic network with gated pricing across 137 US locations.
If you want GLP-1 care with transparent pricing, no commute, and a response often within hours, TelosRX is the direct path. Medi-Weightloss is a strong fit if you prefer hands-on, in-person visits and structured clinic appointments with weekly weigh-ins.
Start your intake →Quick comparison: TelosRX vs Medi-Weightloss
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth pharmacy focused on GLP-1 weight management. It offers compounded tirzepatide and semaglutide, with two formats most clinics do not carry: oral tirzepatide (needle-free, dissolves under the tongue) and microdosed tirzepatide for a gentler titration start.
The service is fully asynchronous — there is no appointment to book. You complete a short medical intake online, and a US-licensed provider reviews it, typically within a few hours. If approved, medication ships free with 48-hour delivery. You can message your care team at any point, receive dose adjustments as your plan evolves, and get quarterly labs. Pricing is published for every plan before you commit, and you can cancel anytime.
HSA and FSA payments are accepted. Start your intake to see your plan options in minutes.
What is Medi-Weightloss?
Medi-Weightloss is a physician-supervised weight-loss clinic network with more than 137 locations across the United States. Its model is built around in-person care: patients schedule appointments at a local clinic, where they receive a medical history review, body composition analysis, and labs at the new-patient visit.
The program offers a range of medications including brand-name GLP-1s such as Wegovy and Zepbound, compounded semaglutide and tirzepatide, and appetite suppressants like phentermine and phendimetrazine. Staff support and recurring clinic visits — including weekly weigh-ins — are central to the experience.
Pricing is not published publicly and varies by individual; prospective patients are directed to call or visit a clinic for a personalized quote. Insurance may cover some services, and HSA/FSA is accepted at many locations.
Medications: what each program offers
Both programs work within the same drug class. Semaglutide is a GLP-1 receptor agonist; tirzepatide is a dual GLP-1 and GIP agonist. These are the active ingredients in FDA-approved brands like Wegovy and Zepbound. The FDA approved tirzepatide for chronic weight management in 2023.
TelosRX offers compounded tirzepatide and semaglutide — not FDA-approved — prepared by licensed US compounding pharmacies under federal compounding regulations. Its distinctive formats are injectable tirzepatide, oral tirzepatide, and microdosed tirzepatide.
Medi-Weightloss offers both compounded versions (not FDA-approved) and the brand-name FDA-approved drugs Wegovy and Zepbound for eligible patients, along with phentermine and phendimetrazine. The brand options may be covered by insurance depending on the patient's plan. For an overview of prescription weight-loss options, the NIH NIDDK resource on prescription weight-loss medications is a useful reference.
Key takeaway: Medi-Weightloss has a broader medication menu including brand-name GLP-1s. TelosRX offers more format variety for compounded tirzepatide — including needle-free options — with pricing that is fully transparent before you commit.
Pricing and transparency
This is one of the clearest differences between the two programs. TelosRX lists every plan publicly:
- From $49/mo — microdosed tirzepatide, 12-month plan
- $99 first month — standard tirzepatide, 12-month plan
- $149 first month — 6-month plan
- $249 first month — 3-month plan
- $449 first month — single-month plan
Medi-Weightloss takes a different approach. Program fees are individualized and not displayed on the website. Prospective patients are asked to call 1-877-MED-LOSS or visit a location to get a quote. This is common with clinic networks where costs depend on services used, labs ordered, and insurance coverage. Insurance may apply to some components, and HSA/FSA is accepted at many locations.
If knowing the price before starting is important to you, TelosRX gives you that upfront. Start your intake to view all plan options.
How the process works
TelosRX is fully asynchronous. You complete a short medical intake online — no appointment needed. A US-licensed provider reviews your intake, typically within a few hours. If approved, medication ships with free 48-hour delivery to your door. Subject to medical approval by a licensed provider.
Medi-Weightloss begins with a free assessment appointment at a local clinic. From there, patients have a new-patient visit that includes labs, body composition analysis, and a personalized plan. Ongoing visits — often weekly — track progress in person. This structure suits patients who want a regular, accountable clinic rhythm and in-person contact with their medical team.
Coaching and ongoing support
TelosRX provides ongoing care through care-team messaging, dose adjustments as your weight-loss progress evolves, and quarterly labs — all remotely. You can reach your care team between visits without scheduling a call.
Medi-Weightloss structures support through scheduled in-person visits. Patients describe regular weigh-ins and close interaction with clinic staff as a meaningful part of accountability. If face-to-face coaching and the social structure of a clinic environment motivate you, that is a genuine strength of the Medi-Weightloss model.
Safety and medical oversight
Both programs require medical evaluation before any prescription is issued. Neither prescribes automatically.
At TelosRX, your intake is reviewed by a licensed provider who screens for contraindications — including personal or family history of medullary thyroid cancer, pancreatitis, and active pregnancy. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Labs are included quarterly to monitor progress.
At Medi-Weightloss, labs are taken at the new-patient visit as part of the clinical evaluation, and ongoing visits allow the physician team to monitor vitals and adjust the plan. GLP-1 medications are prescription-only and not appropriate for everyone — full medical history disclosure during intake is essential for both services.
Which service is right for you?
Best for people who want transparent pricing from $49/mo, a fully online experience with no appointments, needle-free options, and responsive care-team support from a LegitScript-certified telehealth pharmacy.
Best for people who prefer regular in-person clinic visits, weekly accountability with a medical team, and access to brand-name GLP-1s like Wegovy and Zepbound — if a clinic location is nearby.
For most people who want to get started quickly without a clinic commute and see their costs upfront, TelosRX is the more direct path. If in-person accountability is what keeps you on track, Medi-Weightloss's clinic model has real value.
Frequently Asked Questions
Is TelosRX a legitimate medical program?
Yes. TelosRX is LegitScript-certified — the same accreditation standard used by Google and Meta to vet online pharmacies and telehealth providers. Every prescription is subject to medical approval by a licensed provider, and medications are compounded by licensed US compounding pharmacies under federal compounding regulations.
Does Medi-Weightloss offer online or telehealth appointments?
Based on publicly available information, Medi-Weightloss is structured around in-person clinic visits at its 137-plus US locations. The program emphasizes physician-supervised, in-person care. If you need a fully online option, TelosRX is designed specifically for that — no appointments, no commute.
Are the GLP-1 medications at TelosRX FDA-approved?
No. Compounded tirzepatide and semaglutide are not FDA-approved. They are prepared under federal compounding regulations by licensed US compounding pharmacies. Brand-name versions such as Wegovy and Zepbound are FDA-approved; TelosRX focuses on compounded options, while Medi-Weightloss offers both compounded and brand-name GLP-1s.
How much does TelosRX cost compared to Medi-Weightloss?
TelosRX publishes all pricing: from $49/mo for microdosed tirzepatide on a 12-month plan, and $99 for the first month of standard tirzepatide on a 12-month plan. Medi-Weightloss does not publish pricing publicly — fees vary by individual and are provided after contacting a clinic or calling 1-877-MED-LOSS.
What makes Medi-Weightloss different from online GLP-1 programs?
Medi-Weightloss's distinguishing feature is its in-person, physician-supervised clinic model. Patients receive labs, body composition analysis, and regular weigh-ins at a physical location with a dedicated medical team. This structure appeals to patients who find face-to-face accountability important for staying consistent with a weight-loss program.
Can I switch from Medi-Weightloss to TelosRX?
You can start a TelosRX intake at any time. During intake you share your medical history, current medications, and goals. A licensed provider reviews that information before any medication is approved, subject to medical evaluation. Many people explore both options before deciding which model fits their lifestyle.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.
Start your private evaluation at TelosRX.