Choosing between TelosRX and NewSelf for GLP-1 weight loss comes down to price, commitment structure, and format. TelosRX is as low as $99 a month, with monthly flexibility and needle-free oral options. NewSelf is a LegitScript-certified, high-volume telehealth brand with flat per-dose pricing from $99.97 a month, but its lowest rate requires prepaying a 3-month supply upfront. Both require approval by a licensed provider.
For needle-free oral options, quarterly labs, and monthly flexibility, TelosRX is the simpler start. NewSelf fits if you want a large, LegitScript-certified brand and don't mind prepaying three months to unlock its lowest rate.
Start your intake →Quick comparison: TelosRX vs NewSelf
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth pharmacy. It focuses on GLP-1 weight management with compounded tirzepatide and semaglutide.
The service is asynchronous. You finish a short intake online, and a US-licensed provider reviews it, usually within a few hours. There is no appointment to book.
Medications are compounded by licensed US pharmacies and shipped to your door. You can message your care team anytime, and pricing is published upfront and stays flat as your clinician titrates your dose, so there are no surprises.
Browse the tirzepatide and semaglutide options, or start your treatment.
What is NewSelf?
NewSelf is a LegitScript-certified telehealth brand offering compounded Tirzepatide+ (formulated with B6 and glycine) and Semaglutide+ (formulated with B12 and glycine). It reports access to more than 1,000 board-certified physicians across all 50 states and a 4.5-star Trustpilot rating.
The process starts with a short quiz and a free doctor visit. NewSelf highlights fast turnaround, with medication shipped in as little as four days from signup, and it does not require insurance or a membership fee.
NewSelf's lowest advertised rate is tied to a 3-month supply paid upfront rather than a flexible month-to-month plan, and separate add-on products like B12 and ondansetron are priced individually rather than bundled into the GLP-1 program.
Medications: what each program offers
Both programs center on the same drug class. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP agonist.
These ingredients are studied for weight management and are the basis of FDA-approved brands like Wegovy and Zepbound. The compounded versions offered by both TelosRX and NewSelf are not FDA-approved.
TelosRX offers both molecules as weekly injections, plus needle-free oral tirzepatide and a microdosed tirzepatide option. NewSelf offers its Tirzepatide+ and Semaglutide+ formulas as injections, with B6, B12, and glycine blended in; no oral GLP-1 option is listed. For background, see the NIH NIDDK overview and the FDA note on tirzepatide for weight management.
Key takeaway: Both keep pricing flat regardless of dose and are LegitScript-certified. TelosRX is as low as $99 a month, adds needle-free oral and microdosed tirzepatide with anti-nausea support built in, and lets you commit monthly instead of prepaying three months. NewSelf stands out for its large physician network and fast, overnight shipping.
Pricing and transparency
Both companies publish pricing directly on their sites. TelosRX lists every plan before you sign up:
- As low as $99 a month, compounded semaglutide
- As low as $116 a month, microdosed tirzepatide
- As low as $129 a month, needle-free oral tirzepatide
- As low as $139 a month, standard injectable tirzepatide
NewSelf's headline rate is $99.97 a month for Semaglutide+ and $144.49 a month for Tirzepatide+, both tied to prepaying a 3-month supply. Its standard monthly rate without that prepay runs $134.99 for Semaglutide+ and $224.99 for Tirzepatide+. B12 and ondansetron are sold separately at roughly $74 a month each. TelosRX also accepts FSA and HSA and charges no membership fee. Start your intake to see your TelosRX plan price in minutes.
How the process works
Both services are online, so there is no clinic visit. TelosRX intake takes about five minutes. A licensed provider reviews it asynchronously, often within hours, and approved medication ships with free 48-hour delivery. TelosRX is fully asynchronous, with no appointment required, and plans are available monthly with no long-term lock-in.
NewSelf uses a short intake quiz followed by a free doctor visit. Once approved, it ships a 3-month supply upfront, which the company frames as eliminating refill delays, with turnaround as fast as 24 hours and overnight shipping. Neither service prescribes automatically, and any medication is subject to medical approval by a licensed provider.
Coaching and ongoing support
TelosRX leans into clinical monitoring. You get unlimited messaging with your care team, dose adjustments as your body changes, and quarterly labs.
NewSelf emphasizes its network of more than 1,000 board-certified physicians and fast doctor access. Structured lab work and ongoing coaching are not detailed on its product pages.
One is not strictly better. NewSelf leans on physician volume and shipping speed. TelosRX adds lab-based monitoring and monthly flexibility.
Safety and medical oversight
Both programs are LegitScript-certified and gate medication behind a licensed provider. No one is prescribed automatically.
GLP-1 medications are not for everyone. Providers screen for issues like a personal or family history of medullary thyroid cancer, pancreatitis, and pregnancy. Side effects can include nausea and digestive changes, especially early on; NewSelf sells ondansetron separately for nausea, and TelosRX's oral formulations include ondansetron, an anti-nausea medication, in every dose at no added cost.
TelosRX includes quarterly labs and care-team messaging, so concerns get flagged. Share your full history during intake, since approval is subject to medical review.
Which service is right for you?
Best for needle-free oral and microdosed tirzepatide with anti-nausea support built in, monthly flexibility, and quarterly-lab clinical support.
Best if you want a large, LegitScript-certified physician network with fast overnight shipping and don't mind prepaying three months for the lowest rate.
For most people who want a needle-free start with monthly flexibility, TelosRX is the more straightforward choice. If a large physician network and fast shipping matter most, and a 3-month prepay works for your budget, NewSelf is worth a look.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth pharmacy. Medications are compounded by licensed US pharmacies, and every prescription is subject to medical approval by a licensed provider.
Are the GLP-1 medications FDA-approved?
The compounded tirzepatide and semaglutide offered by both TelosRX and NewSelf are not FDA-approved. They are prepared under federal compounding regulations by licensed US pharmacies.
How much does TelosRX cost compared to NewSelf?
TelosRX publishes its pricing, as low as $99 a month for compounded semaglutide, with microdosed tirzepatide as low as $116 a month, needle-free oral tirzepatide as low as $129 a month, and standard injectable tirzepatide as low as $139 a month. NewSelf's lowest rate is $99.97 a month for Semaglutide+ or $144.49 a month for Tirzepatide+, both tied to a 3-month upfront prepay; its standard monthly rate is $134.99 and $224.99.
Do I have to commit to three months with TelosRX?
No. TelosRX offers a monthly plan and you can cancel anytime. NewSelf's lowest advertised rate is tied to prepaying a 3-month supply upfront.
What does NewSelf offer that TelosRX does not?
NewSelf highlights a network of more than 1,000 board-certified physicians, overnight shipping, and turnaround as fast as 24 hours. TelosRX focuses on compounded GLP-1 weight loss with needle-free oral and microdosed tirzepatide, built-in anti-nausea support, quarterly labs, flat dose pricing, and monthly flexibility.
Does NewSelf offer needle-free GLP-1 options?
NewSelf's product pages describe Tirzepatide+ and Semaglutide+ as injectable programs; no oral GLP-1 option is listed. TelosRX offers needle-free oral tirzepatide and a microdosed tirzepatide option alongside its standard injectable plans.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service. Competitor details and pricing were checked in July 2026 against NewSelf's public website and may change.
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