TelosRX vs Polly: choosing between TelosRX and Polly for GLP-1 weight loss comes down to what you value. TelosRX publishes transparent, tiered pricing from $49 a month and runs a fast, fully online process. Polly offers flat all-inclusive pricing and a broader menu that extends beyond GLP-1 care. Both require approval by a licensed provider.
TelosRX is the simpler, more transparent choice. Every plan price is listed upfront, the intake takes about five minutes, and a provider reviews it asynchronously. Polly fits if you want flat all-inclusive weekly pricing and a wider treatment menu.
Start your intake →Quick comparison: TelosRX vs Polly
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, asynchronous telehealth service. You complete a short online intake, and a US-licensed provider reviews it without an appointment. Most reviews happen within hours. If approved, your medication ships fast.
The program focuses on compounded GLP-1 weight management. That includes compounded tirzepatide and compounded semaglutide, prepared by licensed US pharmacies. Compounded medications are not FDA-approved. TelosRX is LegitScript-certified.
Pricing is published upfront. You see every plan price before you start, with no gated quotes. That transparency is the core difference many people notice first.
You can read more about tirzepatide and semaglutide on our product pages. Ready to begin? Start your treatment with a quick online intake.
What is Polly?
Polly, formerly Piper, is an online weight loss and metabolic health service. It offers compounded semaglutide and compounded tirzepatide, prepared by licensed US compounding pharmacies. It is available in all 50 states.
Polly uses a flat, all-inclusive pricing model. The monthly rate does not rise as your dose increases, and it bundles the medication, provider consultation, supplies, and free next-day shipping. There is no membership fee. Care is managed through a patient portal with ongoing provider oversight.
Polly also offers treatments beyond GLP-1 care, including NAD+ and sermorelin. If you want a broader menu under one roof with flat weekly pricing, that breadth is a genuine strength.
Medications: what each program offers
Both services center on two GLP-1 medications. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP receptor agonist. Both support weight management when prescribed and supervised by a licensed provider.
TelosRX also offers options many programs do not. You can explore needle-free oral tirzepatide and lower-dose microdosed tirzepatide. These give more ways to match a plan to your needs and budget.
Compounded versions of these medications are not FDA-approved. For background on how prescription medications support weight management, see the NIH NIDDK overview and this FDA announcement on chronic weight management medication.
Key takeaway: TelosRX publishes every plan price upfront, with options from $49 a month, so you can compare the full cost before you commit.
Pricing and transparency
TelosRX lists every plan price on the site. Here is the structure at a glance:
- From $49/mo for microdosed tirzepatide on a 12-month plan.
- $99 first month for standard tirzepatide on a 12-month plan, then plans scale by length.
- $145, $199, or $399 first month for 6-month, 3-month, or single-month standard tirzepatide plans.
Polly uses flat all-inclusive pricing, with compounded semaglutide around $135 per week and tirzepatide around $199 per week. That flat rate is easy to understand, though the weekly framing makes the lowest entry point higher than TelosRX. You can compare every TelosRX tier before you start. Begin your intake to see what fits.
How the process works
TelosRX keeps it simple. You complete a roughly five-minute online intake. A US-licensed provider reviews it asynchronously, often within hours. There is no appointment to schedule. If approved, your medication ships with free 48-hour shipping.
Polly works similarly. You fill out a free online questionnaire that takes about ten minutes. An independent licensed clinician reviews it the same day. If approved, medication ships free next-day in temperature-controlled packaging. Both services skip the in-person clinic visit, so the main difference is the small details: TelosRX leans on speed and tiered pricing, while Polly leans on flat all-inclusive billing. Any medication is subject to medical approval by a licensed provider.
Want to see how fast it is? Start your intake and a provider can review it the same day.
Coaching and ongoing support
Polly manages care through a patient portal. A provider monitors your progress and adjusts your treatment as needed, and supplies ship with each order. That bundled, hands-on portal experience is a real strength for people who want everything in one place.
TelosRX gives you unlimited care-team messaging, dose adjustments, and quarterly labs. You can reach the care team anytime between shipments. If your needs change, the provider can adjust your dose without a new appointment. Both models keep a licensed provider involved in your ongoing plan, so you are never managing this alone.
Safety and medical oversight
Every plan is provider-gated. A US-licensed provider reviews your intake before any prescription. GLP-1 medications are not right for everyone. Providers screen for a personal or family history of medullary thyroid cancer, a history of pancreatitis, and pregnancy.
Side effects can include nausea and other digestive symptoms, especially early on. These often ease as your body adjusts and as your provider fine-tunes the dose. Quarterly labs help your care team monitor your progress over time. Compounded medications are not FDA-approved, and approval is subject to medical review.
Which service is right for you?
Best for transparent pricing, a fast async start, and a streamlined, medication-first program from a LegitScript-certified pharmacy.
Best for flat all-inclusive weekly pricing and a broader treatment menu that extends beyond GLP-1 care.
If clear upfront pricing and a fast online start matter most, TelosRX is the simpler path. You see every price before you commit, and a provider reviews your intake within hours.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth pharmacy service. Your intake is reviewed by a US-licensed provider before any prescription is written. Medications are compounded by licensed US pharmacies. Compounded medications are not FDA-approved. Approval is subject to medical approval by a licensed provider, and approval is not guaranteed.
Are the GLP-1 medications FDA-approved?
No. TelosRX and Polly both offer compounded semaglutide and tirzepatide. Compounded medications are not FDA-approved. They are prepared by licensed US pharmacies under federal compounding regulations. A US-licensed provider must review your intake and decide if a prescription is appropriate. Approval is not guaranteed.
How much does TelosRX cost compared to Polly?
TelosRX plans start from $49 per month for microdosed tirzepatide on a 12-month plan. Standard tirzepatide is $99 the first month on a 12-month plan. Polly lists flat weekly pricing, with compounded semaglutide around $135 per week and tirzepatide around $199 per week. TelosRX publishes every plan price upfront so you can compare before you start.
Is TelosRX fully online?
Yes. TelosRX is an online-first, asynchronous telehealth service. You complete a short online intake in about five minutes. A US-licensed provider reviews it asynchronously, often within hours. There is no appointment to book. If approved, medication ships with free 48-hour shipping. You can message the care team anytime.
Can I switch from Polly to TelosRX?
Yes. You can start a TelosRX intake anytime, even if you currently use Polly. Complete the short online intake and a US-licensed provider reviews your information. Bring your dose history so the provider has full context. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
How fast is the provider review?
TelosRX uses an asynchronous model, so there is no appointment. After you finish the roughly five-minute intake, a US-licensed provider reviews it, often within hours. If approved, your medication ships with free 48-hour shipping. Polly also uses async intake with same-day provider review through its patient portal.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.
Start your private evaluation at TelosRX.