Comparing TelosRX and RxSpan MD for GLP-1 weight loss starts with a simple gap: TelosRX publishes its prices and RxSpan MD does not. TelosRX plans start at $99 a month for semaglutide. Third-party reviews put RxSpan MD's compounded semaglutide nearer $249 a month. Both are LegitScript-certified, and both require a licensed provider to approve any prescription.
If you want to know the cost before you hand over your details, TelosRX is the clearer choice, and materially cheaper on the figures available. RxSpan MD is worth a look if you want brand-name GLP-1 access, round-the-clock support, or a single platform covering hair, skin and men's health too.
Start your intake →Quick comparison: TelosRX vs RxSpan MD
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed. Individual results vary.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth service focused on GLP-1 weight management.
The process is asynchronous. You complete a short intake online, and a US-licensed provider reviews it, typically within hours. There is no appointment to schedule.
Medications are compounded by licensed US pharmacies and shipped free within 48 hours if approved. Unlimited messaging with your care team, provider-managed dose adjustments and quarterly labs are included at no extra cost. Your monthly price does not change as your dose is titrated.
Compare all four GLP-1 options side by side, or start your treatment.
What is RxSpan MD?
RxSpan MD is a LegitScript-certified telehealth platform with a broad catalog, of which GLP-1 weight management is one part.
On the GLP-1 side it lists three routes: a compounded GLP-1, a brand-name GLP-1 and a microdosing GLP-1 option. Offering all three is a real strength. Brand-name products are FDA-approved, and a microdosing route gives people a gentler way in, so between them RxSpan MD covers a wide range of preferences.
Beyond weight management it also offers NAD+, sermorelin and glutathione injections, minoxidil, finasteride and dutasteride for hair, and tadalafil, sildenafil and vardenafil for sexual health. If you would rather keep several prescriptions under one roof, that breadth has obvious appeal.
The platform highlights free expedited delivery and unlimited 24/7 support from a dedicated team of specialists. Round-the-clock access is a genuine advantage over business-hours support, and worth crediting.
What its site does not do is publish prices. Its GLP-1 pages describe the options without listing a monthly cost, so you learn the number later in the process.
Medications: what each platform offers
Both platforms work with the same drug class. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP agonist. These ingredients form the basis of FDA-approved brands and are widely studied for weight management. For background, see the NIH NIDDK overview and the FDA announcement on tirzepatide for weight management.
RxSpan MD groups its GLP-1 offering into compounded, brand-name and microdosing options. Its published pages do not name an oral or sublingual GLP-1, so injections appear to be the route for its compounded line.
TelosRX offers injectable semaglutide and injectable tirzepatide, plus needle-free oral tirzepatide and a microdosed tirzepatide protocol. Both platforms offer a microdosing route, so that is common ground rather than a point of difference. Compounded medications from either platform are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality.
Key takeaway: RxSpan MD covers more ground with brand-name access, a microdosing option and 24/7 support. TelosRX tells you what it costs up front, and on the figures available it costs considerably less.
Pricing and transparency
TelosRX prices by monthly plan, with the visit, medication, shipping, labs and support included:
- Semaglutide, injectable: as low as $99/month, down from $299
- Microdosed tirzepatide: as low as $116/month, down from $279
- Oral, needle-free tirzepatide: as low as $129/month
- Standard injectable tirzepatide: as low as $139/month, down from $399
That figure does not move when your dose does. RxSpan MD does not publish GLP-1 pricing on its site. Independent reviews report compounded semaglutide from about $249 a month and compounded tirzepatide from about $329 a month. Treat those as indicative rather than official, since they come from third parties and not from RxSpan MD itself.
If those figures hold, the gap is large: roughly $150 a month on semaglutide and roughly $190 on tirzepatide. Even allowing for changes, the difference is unlikely to disappear.
There is a separate point here beyond the number. Being able to see the price before you start is how you compare options properly. TelosRX puts it on the page. RxSpan MD asks you to begin the process first.
Neither platform bills insurance, and TelosRX plans are FSA and HSA eligible. Start your intake to see your TelosRX plan in minutes.
How the process works
TelosRX is a guided, fully asynchronous program. The intake takes about five minutes. A US-licensed provider reviews it without an appointment, typically within hours, and approved medication ships with free 48-hour delivery. If you are not approved, you pay nothing.
RxSpan MD routes patients through an online process to licensed providers, with free expedited delivery once a prescription is issued. Its site does not spell out whether every product requires a live consultation or whether review is asynchronous, so it is worth confirming before you commit.
Neither platform prescribes automatically. Any medication is subject to medical approval by a licensed provider. Begin your TelosRX intake to see if you qualify.
Support and ongoing care
RxSpan MD advertises unlimited 24/7 support with a dedicated team of specialists. For anyone who works nights, travels, or simply wants an answer at an awkward hour, that is a strong offering and better than most.
TelosRX includes unlimited messaging with your care team, provider-managed dose adjustments and quarterly labs in every plan. Because pricing is flat, a dose increase is a clinical decision rather than a billing one. RxSpan MD does not describe an included lab program, so ongoing bloodwork appears to sit outside its published offer.
Safety and medical oversight
Both platforms are LegitScript-certified. RxSpan MD displays its seal with a verification link, and TelosRX is certified as a telehealth weight-loss service. Both dispense through licensed US pharmacies and require provider review before any prescription.
GLP-1 medications are not right for everyone. Providers screen for issues including a personal or family history of medullary thyroid cancer, pancreatitis and pregnancy. Side effects are most often digestive, especially early on, and typically ease with gradual dose titration.
Share your full medical history during intake on either platform, since approval is subject to medical review and is not guaranteed.
Which service is right for you?
Best if you want to see the price before you start and keep the monthly cost down: published flat pricing from $99, needle-free oral tirzepatide, a microdosed option, quarterly labs and free 48-hour shipping.
Best if you want brand-name GLP-1 access, value 24/7 support from a dedicated team, or want hair, skin and sexual health prescriptions handled on the same platform.
RxSpan MD is a certified platform with real breadth and unusually good support hours. If you want to know what you will pay before you begin, and want that number to be lower, TelosRX is the more straightforward pick.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth service. Medications are compounded by licensed US pharmacies, and every prescription is subject to medical approval by a licensed provider.
Is RxSpan MD LegitScript certified?
Yes. RxSpan MD displays a LegitScript certification seal on its site along with a link to verify its approval directly with LegitScript.
How much does RxSpan MD cost?
RxSpan MD does not publish GLP-1 pricing on its site. Independent reviews report compounded semaglutide from about $249 a month and compounded tirzepatide from about $329 a month, which should be treated as indicative. TelosRX publishes its pricing openly, as low as $99 a month for semaglutide and $139 for injectable tirzepatide.
Does either service offer a microdosed GLP-1?
Both do. RxSpan MD lists a microdosing GLP-1 option, and TelosRX offers a microdosed tirzepatide protocol as low as $116 a month. This is common ground between the two platforms.
Does either service offer a needle-free GLP-1?
TelosRX offers oral, sublingual tirzepatide as a needle-free alternative to injections. RxSpan MD does not list a needle-free oral or sublingual GLP-1 on its site.
Who is RxSpan MD best for?
RxSpan MD suits someone who wants access to a brand-name GLP-1, values unlimited 24/7 support, and would like hair, skin or sexual health prescriptions on the same platform. If you want published pricing, a lower monthly cost, a needle-free option or included quarterly labs, TelosRX is the closer fit.
TelosRX is LegitScript-certified. Compounded medications from either platform are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service. RxSpan MD details, including catalog and support, were checked against its public website in July 2026. Pricing figures are from third-party reviews, not from RxSpan MD, and may change.
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