Choosing between TelosRX and Sesame Care for GLP-1 weight loss comes down to how you want to see your provider, what you pay for medication, and how much ongoing clinical support matters to you. TelosRX is asynchronous with compounded options from $49/mo; Sesame Care offers synchronous video visits with brand-name GLP-1s, billed separately.
For a lower all-in monthly cost, compounded options, and no scheduled appointment, TelosRX is the simpler start. Sesame Care fits if you prefer a live video visit with a doctor and access to brand-name medications like Wegovy or Zepbound (billed separately).
Start your intake →Quick comparison: TelosRX vs Sesame Care
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth pharmacy focused on GLP-1 weight management. The service is fully asynchronous: you complete a short intake online, and a US-licensed provider reviews it — often within hours — with no appointment to schedule.
Medications are compounded by licensed US pharmacies and shipped free with 48-hour delivery if your prescription is approved. Pricing is published upfront in a single all-in monthly figure, covering medication and care. You can message your care team anytime, adjust your dose as needed, and access quarterly labs.
Browse the tirzepatide and semaglutide options, or explore oral tirzepatide and microdosed tirzepatide for needle-free alternatives.
What is Sesame Care?
Sesame Care is a direct-pay telehealth marketplace connecting patients to board-certified doctors via synchronous video visits. With over 10,000 providers and 383 listed services, it covers a wide range of health needs beyond weight loss — including mental health, women's health, urgent care, and dermatology.
For weight management, Sesame offers access to brand-name GLP-1 medications like Wegovy, Zepbound, Ozempic, Mounjaro, and Rybelsus (as well as newer options like Foundayo). The model is subscription-based for the program, with medication billed separately at self-pay or insurance rates. Sesame is accredited by the Better Business Bureau and has a 4.5-star Trustpilot rating with over 1 million patients served.
Medications: what each program offers
Both programs work with the same drug classes. Semaglutide is a GLP-1 receptor agonist; tirzepatide is a dual GLP-1 and GIP agonist. Both are studied for long-term weight management and form the basis of FDA-approved brands like Wegovy and Zepbound. See the NIH NIDDK overview on prescription weight-loss medications for more clinical background.
Sesame Care's weight loss program centers on brand-name, FDA-approved medications. These are the same formulations sold in pharmacies — Wegovy pens and pills, Zepbound KwikPens, Ozempic, Mounjaro, and Rybelsus. Costs are high at self-pay rates ($149–$698/mo depending on the drug and dose), though insurance may offset some of that. The FDA approval of tirzepatide for chronic weight management is specifically relevant to Zepbound, which Sesame offers.
TelosRX offers compounded tirzepatide and semaglutide — these are not FDA-approved and are prepared under federal compounding regulations by licensed US compounding pharmacies. TelosRX also provides two unique needle-free formats: oral (under-the-tongue) tirzepatide and a microdosed tirzepatide protocol, which can be a meaningful option for patients who prefer to avoid injections.
Key takeaway: Sesame Care's advantage is access to brand-name, FDA-approved GLP-1s — valuable if your insurance covers them. TelosRX's advantage is a lower all-in price, compounded flexibility, and needle-free options — all in an asynchronous, no-appointment format starting from $49/mo.
Pricing and transparency
This is one of the clearest differences between the two services.
TelosRX publishes a single all-in monthly price that includes medication and care:
- From $49/mo — microdosed tirzepatide, 12-month plan
- $99 first month — standard tirzepatide, 12-month plan
- $145, $199, or $399 first month — 6-month, 3-month, or single-month plans
Sesame Care separates program and medication costs:
- Program subscription: $99/mo (month-to-month) or $59/mo (annual plan)
- Medication costs (self-pay): Wegovy pill $149–$299/mo; Wegovy pen $199 for the first two months then $349/mo; Zepbound $299–$698/mo; Ozempic $199 for first two months then $349/mo
- Total all-in for most patients: $250–$800/mo depending on medication choice
If you have insurance that covers brand-name GLP-1s, Sesame's model could make sense. Without insurance, TelosRX's compounded pricing is substantially lower. Both services accept HSA and FSA payments. Start your intake to view your exact TelosRX plan cost.
How the process works
TelosRX is fully asynchronous. You complete a short online intake covering your health history and goals — no appointment required. A licensed US provider reviews your information, typically within hours. If approved, your compounded medication ships free with 48-hour delivery. No video call, no waiting room.
Sesame Care follows a synchronous model. After subscribing, you book a video appointment with one of their board-certified providers, sometimes available the same day. Your provider reviews your history on the call, and if appropriate, prescribes medication that ships to your door or a preferred pharmacy. Follow-up visits and unlimited messaging are included in the subscription.
Neither service prescribes automatically. Any medication is subject to medical approval by a licensed provider, and approval is not guaranteed for either program.
Coaching and ongoing support
TelosRX includes care-team messaging, dose adjustments as your response evolves, and quarterly labs — all built into the program cost. Support is asynchronous, meaning you message your care team and receive responses without scheduling a call.
Sesame Care's subscription includes unlimited provider messaging and follow-up video consultations, giving you the option of face-to-face touchpoints with your doctor. Labs are included and processed through Quest Diagnostics (available in most states). Sesame also offers app-based tracking for diet, exercise, and sleep.
Both offer meaningful ongoing support. The difference is format: Sesame Care suits patients who value synchronous, face-to-face check-ins with a doctor. TelosRX suits patients who prefer flexibility and asynchronous messaging on their own schedule.
Safety and medical oversight
Both programs gate medication behind a licensed provider. Neither prescribes without a clinical review.
GLP-1 medications are not appropriate for everyone. Providers at both services screen for contraindications including personal or family history of medullary thyroid cancer, pancreatitis, and certain other conditions. Pregnancy is also a contraindication. Common side effects include nausea, digestive changes, and appetite shifts — particularly in early weeks.
TelosRX includes quarterly labs and ongoing care-team messaging so concerns can be flagged between visits. Sesame Care includes lab monitoring through Quest Diagnostics and live follow-up video visits for real-time clinical guidance.
Which service is right for you?
Best for patients who want the lowest all-in monthly cost, needle-free or compounded options, and asynchronous care from a LegitScript-certified pharmacy — no appointments needed.
Best for patients who prefer live video visits with a doctor and want access to FDA-approved brand-name GLP-1s like Wegovy or Zepbound — especially if insurance may offset medication costs.
For most people comparing on cost and convenience, TelosRX is the more straightforward path. If seeing a provider face-to-face matters, or if your insurance covers brand-name GLP-1s, Sesame Care is a legitimate option worth exploring.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth pharmacy. Compounded medications are prepared by licensed US compounding pharmacies, and every prescription is subject to medical approval by a licensed provider. Approval is not guaranteed.
Are the GLP-1 medications offered by each service FDA-approved?
Sesame Care offers brand-name, FDA-approved GLP-1 medications — Wegovy, Zepbound, Ozempic, Mounjaro, and Rybelsus. TelosRX offers compounded tirzepatide and semaglutide, which are not FDA-approved. They are prepared under federal compounding regulations by licensed US compounding pharmacies.
How much does TelosRX cost compared to Sesame Care?
TelosRX's all-in pricing starts from $49/mo (microdosed tirzepatide, 12-month plan) with standard tirzepatide from $99 your first month. Sesame Care charges a program subscription ($59–$99/mo) plus medication costs separately, which range from $149 to $698/mo at self-pay rates — making total costs considerably higher without insurance coverage.
Does Sesame Care require a video visit?
Yes. Sesame Care's weight loss program uses synchronous video visits with board-certified doctors, often available the same day. Follow-up visits and unlimited provider messaging are included in the subscription. This contrasts with TelosRX, which is fully asynchronous — no appointment is required.
Does TelosRX offer needle-free GLP-1 options?
Yes. TelosRX offers oral tirzepatide (administered under the tongue) and a microdosed tirzepatide protocol, both of which avoid injections. Sesame Care offers oral brand-name options like Rybelsus and the Wegovy pill for patients who prefer not to inject.
Can I use insurance with either service?
TelosRX accepts HSA and FSA payments but does not bill insurance directly — compounded medications are generally not covered by insurance. Sesame Care operates on a self-pay model for program fees, but brand-name medications may be covered by insurance at a traditional pharmacy, potentially reducing your out-of-pocket medication costs significantly.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.
Start your private evaluation at TelosRX.