Choosing between TelosRX and TMates for GLP-1 weight loss comes down to price and what is bundled in. TelosRX starts at $49 a month and is LegitScript-certified. TMates charges an all-inclusive rate from around $199 a month that bundles coaching and delivery, and it adds phentermine as a non-GLP option. Both use compounded GLP-1 medication and require approval by a licensed provider.
For the lowest entry price and LegitScript-certified care, TelosRX is the simpler start. TMates fits if you want an all-inclusive flat rate with coaching and nutrition guidance, an oral or injectable choice, or phentermine alongside GLP-1s.
Start your intake →Quick comparison: TelosRX vs TMates
Compounded medications are not FDA-approved. Any prescription is subject to medical approval by a licensed provider, and approval is not guaranteed.
What is TelosRX?
TelosRX is an online-first, LegitScript-certified telehealth pharmacy. It focuses on GLP-1 weight management with compounded tirzepatide and semaglutide.
The service is asynchronous. You finish a short intake online, and a US-licensed provider reviews it, usually within a few hours. There is no appointment to book.
Medications are compounded by licensed US pharmacies and shipped to your door. You can message your care team anytime, and pricing is published upfront, so there are no surprises.
Browse the tirzepatide and semaglutide options, or start your treatment.
What is TMates?
TMates is an online GLP-1 weight-loss service with the tagline Personalized Medicine for a Better Life. You choose a product, complete a short health assessment quiz, and a provider reviews your information before a registered US pharmacy fills your prescription.
TMates offers compounded semaglutide and tirzepatide in oral or injectable form, and it also offers phentermine, an FDA-approved appetite suppressant, as a non-GLP option. It says it serves all 50 states plus Puerto Rico and US territories, with no insurance required and no waitlist.
Pricing is an all-inclusive monthly rate from around $199 that bundles the provider consultation, medication, coaching, and delivery. TMates does not publicly list a LegitScript certification.
Medications: what each program offers
Both programs center on the same drug class. Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP agonist.
These ingredients are studied for weight management and are the basis of FDA-approved brands like Wegovy and Zepbound. The compounded versions offered by both TelosRX and TMates are not FDA-approved.
TelosRX also offers needle-free oral tirzepatide and a microdosed option. TMates offers its compounded GLP-1s in oral or injectable form and adds phentermine, a separate FDA-approved appetite suppressant. For background, see the NIH NIDDK overview and the FDA note on tirzepatide for weight management.
Key takeaway: Both publish prices and use compounded GLP-1s. TelosRX starts much lower, at $49 a month, is LegitScript-certified, and includes quarterly labs. TMates bundles coaching and delivery into an all-inclusive rate from around $199 and adds phentermine as a non-GLP option.
Pricing and transparency
Both companies publish pricing and neither requires insurance. The real difference is the entry point. TelosRX lists every plan before you sign up:
- From $49 a month for microdosed tirzepatide on the 12-month plan
- $99 your first month for standard tirzepatide on the 12-month plan
- $145, $199, or $399 your first month for the 6-month, 3-month, or single-month plans
TMates uses a single all-inclusive rate from around $199 a month that bundles the consultation, medication, coaching, and delivery. Both include medication and support in the price, so the clearest gap is where each one starts. TelosRX also accepts FSA and HSA and charges no membership fee. Start your intake to see your TelosRX plan price in minutes.
How the process works
TelosRX is asynchronous, so there is no appointment to schedule. The intake takes about five minutes. A licensed provider reviews it, often within hours, and approved medication ships with free 48-hour delivery.
TMates uses a short health assessment quiz followed by provider review, after which a registered US pharmacy fills approved prescriptions and ships to your door. Neither service prescribes automatically, and any medication is subject to medical approval by a licensed provider.
Coaching and ongoing support
TelosRX leans into clinical monitoring. You get unlimited messaging with your care team, dose adjustments as your body changes, and quarterly labs.
TMates leans into coaching. Its all-inclusive rate bundles personalized coaching, nutrition guidance, progress tracking, and 24/7 support.
One is not strictly better. TMates suits people who want coaching and nutrition guidance included in a flat rate. TelosRX suits people who want responsive clinical messaging and lab-based monitoring.
Safety and medical oversight
Both programs gate medication behind a licensed provider. No one is prescribed automatically.
GLP-1 medications are not for everyone. Providers screen for issues like a personal or family history of medullary thyroid cancer, pancreatitis, and pregnancy. Side effects can include nausea and digestive changes, especially early on.
TelosRX includes quarterly labs and care-team messaging, so concerns get flagged. Share your full history during intake, since approval is subject to medical review. If certification matters to you, you can verify any telehealth provider on the LegitScript website.
Which service is right for you?
Best for the lowest entry price, needle-free and microdosed options, quarterly-lab clinical support, and LegitScript-certified care.
Best if you want an all-inclusive flat rate with coaching and nutrition guidance, an oral or injectable choice, or phentermine as a non-GLP option, with nationwide coverage.
For most people who want a low-cost, transparent start with ongoing labs and LegitScript-certified care, TelosRX is the more straightforward choice. If an all-inclusive coaching bundle or phentermine is a priority, TMates is worth a look.
Frequently Asked Questions
Is TelosRX legitimate?
Yes. TelosRX is a LegitScript-certified telehealth pharmacy. Medications are compounded by licensed US pharmacies, and every prescription is subject to medical approval by a licensed provider.
Are the GLP-1 medications FDA-approved?
The compounded tirzepatide and semaglutide offered by both TelosRX and TMates are not FDA-approved. They are prepared under federal compounding regulations. TMates also offers phentermine, which is an FDA-approved appetite suppressant.
How much does TelosRX cost compared to TMates?
TelosRX publishes its pricing, starting from $49 a month (microdosed tirzepatide, 12-month plan), with standard tirzepatide from $99 your first month. TMates uses an all-inclusive monthly rate from around $199 that bundles the consultation, medication, coaching, and delivery.
Is TelosRX fully online?
Yes. TelosRX is online-first and asynchronous. You finish a short intake, a licensed provider reviews it, and approved medication ships to you. No appointment is required.
What does TMates offer that TelosRX does not?
TMates offers phentermine as a non-GLP appetite suppressant, bundles coaching and nutrition guidance into an all-inclusive rate, and says it serves all 50 states plus Puerto Rico and US territories. TelosRX focuses on compounded GLP-1s with needle-free oral and microdosed options, quarterly labs, and LegitScript-certified care.
Is TMates LegitScript-certified?
TMates does not publicly list a LegitScript certification, and we make no claim either way. TelosRX is LegitScript-certified. You can look up the certification status of any telehealth provider on the LegitScript website.
TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.
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